Graziella is a Professor at the University of Modena and Reggio Emilia and Cell Therapy Program Coordinator at the Centre for Regenerative Medicine “Stefano Ferrari”. She is also co-founder and R&D Director at Holostem Terapie Avanzate S.r.l.
Prof. Pellegrini is known for her work in translational medicine, and has developed epithelial stem cell-mediated cell and gene therapies. She has used epithelial stem cells for the treatment of severe eye and skin disease, establishing the first successful clinical trial to treat junctional epidermolysis bullosa and developed a culture system that creates limbal stem cells for the regeneration of corneas, able to restore vision to patients with ocular burns. This system, Holoclar®, was recognized by the European Medicines Agency in 2008, and is the first stem cell based medicinal product to be approved by the European Commission. Between 2018 and 2020, Prof. Pellegrini shared the ISSCR and Louis-Jeantet Prize, with Michele De Luca, as well as winning the TERMIS and European Tech Women Award amongst others, for the development of epithelial stem cell-based regenerative therapy in patients with severe eye and skin disease.
Prof. Pellegrini has published over 100-peer reviewed papers and book chapters, 9 patents, and is a founding member of the International Ocular Surface Society. She is also a member, speaker, or chair of numerous scientific societies, international committees and meetings covering stem cells and regenerative medicine.