Transforming the lives of patients through a pipeline of clinically feasible in vivo reprogramming therapies.
About
Mogrify
Mogrify’s mission is to transform the lives of patients through the development of a novel class of in vivo reprogramming therapies, initially addressing indications in otology, ophthalmology, diabetes, and other disease areas with a high unmet clinical need. Using its proprietary suite of platform technologies to systematically identify the key transcriptomic and epigenetic switches required to drive direct cellular reprogramming, the Company is able to recover cell types lost as result of disease or injury to restore organ function directly in situ. MOGRIFY® is a direct cellular reprogramming platform, which leverages transcriptomic data to identify optimal combinations of transcription factors for the conversion, via enhanced forward programming or transdifferentiation, of any cell type into any other cell type. epiMOGRIFY® is a cell identity platform, which leverages epigenetic data to identify optimal combinations of transcription factors or growth factors required to maintain cell identity and epigenetically support the reprogramming of cells in chemically defined media.
Our
HISTORY
2009
FANTOM 5 LAUNCH
RIKEN scientists launch an international consortium to provide insight into the regulatory landscape of the transcriptome across as many cell states as possible.
•
2009
FANTOM 5 LAUNCH
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2014
MOGRIFY VALIDATION
Collaboration with Jose Polo to test cell conversions begins and three conversions are validated in just several months.
•
2014
Mogrify Validation
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2016
NATURE GENETICS
MOGRIFY® V1 platform and cell conversions results published in Nature Genetics journal featuring on the front page.
•
2016
Nature Genetics
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2019
GROWTH PHASE
$3.7M seed capital raised, Dr. Darrin M. Disley, OBE appointed as CEO, and Dr. Jane Osbourn, OBE appointed as Chair, before raising a further $16 million in the initial close of Series A funding.
•
2018/2019
Investment & Team
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2020
CELL SYSTEMS
epiMOGRIFY® cell identity platform and validation published in Cell Systems journal.
•
2018/2019
Investment & Team
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2024
PROOF OF CONCEPT
In vivo reprogramming portfolio validated to clinically relevant ex vivo / in vivo proof of mechanism/concept.
•
2018/2019
Investment & Team
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2011
MOGRIFY DEVELOPMENT
Julian Gough and Owen Rackham begin the V1 platform development using the unpublished FANTOM 5 consortium data.
•
2011
Mogrify Development
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2015
FOUNDATION PATENT
Julian Gough, Owen Rackham, Jose Polo file a patent application for the V1 platform and over 30 direct cell conversions.
•
2015
Foundation Patent
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2016/2018
INCORPORATION
Mogrify is incorporated in February 2016 by the three academic Co-founders: J. Gough, O. Rackham & J. Polo with pre-seed and grant funding to begin the industrial development and application of the V1 platform.
•
2016
Incorporation
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2020
COMMERCIALIZATION
First milestone & royalty-bearing deals executed based on MOGRIFY validation. Appointed Dr. Lorenz Mayr, Prof. Graziella Pellegrini, and Prof. Christine Mummery to the Scientific Advisory Board (SAB).
•
2016
Incorporation
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
2021-2023
PORTFOLIO ADVANCEMENT
Additional closes bring total raised in Series A to £35 million GBP ($46 million USD) supporting the selection and advancement of in vivo reprogramming concepts through pre-clinical development. Exclusive licensing of the epiMOGRIFY® cell identity platform. Tom Graney appointed to non-executive board.
•
2016
Incorporation
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Rutrum quisque non tellus orci ac auctor augue mauris augue. Neque volutpat ac tincidunt vitae semper quis lectus nulla at. Nunc aliquet bibendum enim facilisis. Enim tortor at auctor urna nunc id cursus. Aliquet sagittis id consectetur purus. Neque viverra justo nec ultrices dui. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Ultrices neque ornare aenean euismod elementum nisi quis eleifend quam. Sed faucibus turpis in eu.
Our
SCIENCE
Mogrify has developed a proprietary suite of platform technologies that utilize a systematic big-data approach to direct cellular reprogramming (Rackham et al., Nature Genetics, 2016) and the maintenance of cell identity (Kamaraj et al., Cell Systems 2020). The platforms, developed over a 12-year period via a multi-national research collaboration, deploy next-generation sequencing, gene regulatory and epigenetic network data to enable the prediction of the transcription factors and culture medium conditions required to produce any target cell type from any source cell type. Mogrify is applying this approach to generate the functional cell types required to transform the lives of patients, by delivering a novel class of in vivo reprogramming therapies across otology, ophthalmology, diabetes, and other disease areas with a high unmet clinical need.
Mogrify
PARTNERING & INVESTING
Mogrify is looking to partner with disruptive innovators in the fields of regenerative medicine, in vivo reprogramming, and other cell-based therapies to develop treatments for indications of high unmet clinical need. We are particularly interested in speaking with those with interest in otology, ophthalmology, and diabetes, as well as other disease areas where these modalities may be of interest. Mogrify is commercializing its technology via a combination of in vivo reprogramming therapy development, co-development partnerships, as well as the exploitation of the platform in other therapeutic and non-therapeutic applications.
Current
Investors
Ahren Innovation Capital
Ahren LP is an investment fund that supports transformational companies at the cutting edge of deep science and deep tech. The technologies of its Founding Partners are today valued more than $100 billion combined. A group of highly diverse, creative and original thinkers leading their domains, Ahren believes in taking considered risk that will deliver superior rewards— capturing a generational opportunity to provide smart capital to deep technology pioneers. With a philosophy espousing the importance of relationships and trust, Ahren provides long-term capital and support to exceptional founders and teams, empowering them to achieve the unimaginable. Ahren Innovation Capital was founded by Alice Newcombe-Ellis, together with Science Partners Sir Shankar Balasubramanian, Professor John Daugman, Professor Zoubin Ghahramani, Professor Steve Jackson, Professor Andy Parker, Sir Venki Ramakrishnan, Lord Martin Rees and Sir Gregory Winter.
ASTELLAS VENTURE MANAGEMENT LLC
Astellas Venture Management LLC (AVM) is the corporate venture capital organization dedicated to reinforcing Astellas Pharma Inc. (Astellas) to accomplish the strategic goals. The venture capital activity of AVM is designated since 2005. Astellas, the ultimate parent company of AVM, headquartered in Tokyo is actively engaged in business as an R&D-driven global pharmaceutical company with the business philosophy to “Contribute toward improving the health of people around the world through the provision of innovative and reliable pharmaceutical products”. Through strategic investments in private early-stage companies, the funds aim to mutual-interact with Astellas, leading to partnering/collaboration in the future. AVM will be able to provide portfolio companies with invaluable R&D advice and assistance.
TREND INVESTMENT GROUP
Trend Investment Group is a Guernsey-based Venture Capital fund focused on the investment of biotech, healthcare, deep tech companies across the UK, Europe, and the US. We have a close collaborative and inclusive team of partners consisting of entrepreneurs, scientists, academic researchers, and financial experts with extensive investment experience from pre-series A to pre-IPO. Since establishment in 2016, Trend has invested in over 20 high potential and high growth start-ups. We are also committed to supporting companies’ growth by fostering collaborations and sharing our industry insight, market knowledge, and resources.
DR. DARRIN M. DISLEY OBE
Darrin is a renowned scientist, entrepreneur, angel investor and enterprise champion who has started, grown, or invested in over 40 start-up life science, technology and social enterprises, raising $600 million USD in business financing and closing $700 million USD in commercial deals. He was CEO of Horizon Discovery Group plc for 11 years, during which he led the Company from start-up through a $113 million USD IPO, and rapid scale-up powered by multiple acquisitions of US peer companies to become a global market leader in gene editing and gene modulation technologies. He was awarded a lifetime Queen’s Award for Enterprise Promotion in 2016 for his work in promoting enterprise across the UK and appointed OBE in 2018 for his services to business and enterprise in the healthcare sector.
DR. JONATHAN MILNER
Jonathan, Founder of Abcam plc, is an experienced entrepreneur and investor and is passionate about supporting UK life science and high-tech start-ups. He has provided considerable investment and support to over 60 companies and has assisted three technology companies to IPO on the London AIM Stock exchange.
Jonathan gained his doctorate in Molecular Genetics at Leicester University after graduating in Applied Biology at Bath. From 1992–95, he was a post-doctoral researcher at Bath, following which he worked at the University of Cambridge in the lab of Professor Tony Kouzarides studying cancer. He identified the market opportunity for supplying high-quality antibodies to support protein interaction studies, and in 1998, founded Abcam with David Cleevely and Professor Tony Kouzarides.
Jonathan is Chairman of Axol Bioscience Ltd and Camallergy Ltd and non-executive director of PhoreMost Ltd, Syndicate Room Ltd and HealX Ltd.
JOE CADDELL
Joe has an honours degree in Physics and Theoretical Physics and a Masters in Engineering. He has a lifelong interest in science and technology in all their forms.
He began his career in Information Technology, coding in mainframe assembler, and went on to lead software development teams and large-scale IT infrastructure operations across multiple industries and countries.
Joe is an active early-stage angel investor, focusing primarily on high-potential technology start-ups. He initially invested in Mogrify’s seed round and has been committed to realizing the technology’s potential for in vivo reprogramming and other therapeutic applications ever since.
Outside of Mogrify, Joe is currently a director of Ceryx Medical, which is developing a novel treatment for heart failure. Its external device is in human safety trials in hospitals in Australia, New Zealand and the UK.
