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Our Mission

Transforming the development of ex vivo cell therapies and pioneering the field of in vivo reprogramming therapies.

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About

Mogrify

Mogrify® has developed a proprietary suite of platform technologies that enable systematic identification of the key transcriptomic and epigenetic switches that drive the speed, efficiency and maintenance of cell reprogramming. MOGRIFY® is a direct cellular reprogramming platform, which leverages transcriptomic data to identify optimal combinations of transcription factors for the conversion, via enhanced forward reprogramming or transdifferentiation, of any cell type into any other cell type. epiMOGRIFY is a cell identity platform, which leverages epigenetic data to identify optimal combinations of transcription factors or growth factors required to maintain cell identity and epigenetically support the reprogramming of cells in chemically defined media. Mogrify is deploying these platforms to develop scalable ex vivo cell therapies and in vivo reprogramming therapies for immuno-oncology, ophthalmology and other diseases with a high unmet clinical need.

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Our

HISTORY

2009

FANTOM 5 LAUNCH

RIKEN scientists launch an international consortium to provide insight into the regulatory landscape of the transcriptome across as many cell states as possible.

2014

MOGRIFY VALIDATION

Collaboration with Jose Polo to test cell conversions begins and three conversions are validated in just several months.

2016

NATURE GENETICS

Mogrify V1 platform and cell conversions results published in Nature Genetics journal featuring on the front page.

2018/2019

GROWTH PHASE

$3.7M seed capital raised, Dr. Darrin M. Disley, OBE appointed as CEO, and Dr. Jane Osbourn, OBE appointed as Chair, hired 40 scientists and raised an additional $16 million in the initial close of Series A funding.

2020

CELL SYSTEMS

epiMOGRIFY cell identity platform and validation published in Cell Systems journal.

2011

MOGRIFY DEVELOPMENT

Julian Gough and Owen Rackham begin the V1 platform development using the unpublished FANTOM 5 consortium data.

2015

FOUNDATION PATENT

Julian Gough, Owen Rackham, Jose Polo file a patent application for the V1 platform and over 30 direct cell conversions.

2016/2018

INCORPORATION

Mogrify is incorporated in February 2016 by the three academic Co-founders: J. Gough, O. Rackham & J. Polo with pre-seed and grant funding to begin the industrial development and application of the V1 platform.

2020

PROOF OF CONCEPT

First milestone & royalty-bearing deals executed. Appointed Dr. Lorenz Mayr, Prof. Graziella Pellegrini, Prof. Giulio Cossu and Prof. Christine Mummery to the Scientific Advisory Board (SAB). Progression of internal programs to in vitro and in vivo proof-of-concept stage.

2021

ROAD TO IND

Second close of $17 million brings total raised in Series A to $33 million supporting the advancement of immuno-oncology and ophthalmology programs through to IND-enabling studies.

Our

SCIENCE

Mogrify has developed a proprietary suite of platform technologies that utilize a systematic big-data approach to direct cellular reprogramming (Rackham et al., Nature Genetics, 2016) and the maintenance of cell identity (Kamaraj et al., Cell Systems 2020). The platforms, developed over a 12-year period via a multi-national research collaboration, deploy next-generation sequencing, gene regulatory and epigenetic network data to enable the prediction of the transcription factors and culture medium conditions required to produce any target cell type from any source cell type. Mogrify is applying this approach to generate the scalable source of functional cell types required to transform the development and manufacture of ex vivo cell therapies and pioneer a new class of in vivo reprogramming therapies, positioning the company to address a rapidly growing regenerative medicine market estimated to be worth a $39 billion USD by 2023.

Learn more about MOGRIFY® & EpiMOGRIFY

Mogrify

PARTNERING & INVESTING

Mogrify is looking to partner with disruptive innovators in the fields of regenerative medicine, ex vivo cell therapy and in vivo reprogramming therapy to develop treatments for indications of high unmet clinical need. We are particularly interested in speaking with those with interest in immuno-oncology, ophthalmology as well as other disease areas where these modalities may be of interest. Mogrify is commercializing its technology via a combination of internal therapy development and co-development partnerships, as well as the exploration and generation of novel cell-based and in vivo reprogramming therapies for broad therapeutic application.

Partnering
Investing

Current

Investors

mogrify investor parkwalk

Parkwalk Advisors

Parkwalk has been the UK’s most active investor in world-changing technologies emerging from the UK’s leading universities and research institutions over the past five years. It currently has £300 million of assets under management, and has invested in over 120 companies across its flagship Parkwalk Opportunities EIS Fund as well as the award-winning enterprise and innovation funds Parkwalk manages for the Universities of Cambridge, Oxford and Bristol. Parkwalk offers investors and partners access to a unique and diverse deal pipeline. Investing from pre-seed through to later stage, these knowledge-intensive technologies are well tested and IP-protected, sitting at the cutting edge of innovation and creating solutions to real-world challenges.

Ahren Innovation Capital

Ahren LP is an investment fund that supports transformational companies at the cutting edge of deep science and deep tech. The technologies of its Founding Partners are today valued more than $100 billion combined. A group of highly diverse, creative and original thinkers leading their domains, Ahren believes in taking considered risk that will deliver superior rewards— capturing a generational opportunity to provide smart capital to deep technology pioneers. With a philosophy espousing the importance of relationships and trust, Ahren provides long-term capital and support to exceptional founders and teams, empowering them to achieve the unimaginable. Ahren Innovation Capital was founded by Alice Newcombe-Ellis, together with Science Partners Sir Shankar Balasubramanian, Professor John Daugman, Professor Zoubin Ghahramani, Professor Steve Jackson, Professor Andy Parker, Sir Venki Ramakrishnan, Lord Martin Rees and Sir Gregory Winter.

Mogrify investor 24haymarket

24HAYMarket

24Haymarket is a private capital investment firm focused on investing in high growth UK companies. 24Haymarket’s Investor Network includes several highly experienced private equity and venture capital investors, seasoned entrepreneurs and senior operators. We invest our own capital in direct alignment with entrepreneurs and typically seek Board representation to actively support their growth agenda. Since inception in 2011, 24Haymarket has invested over £80 million in more than 50 high-growth businesses.

ASTELLAS VENTURE MANAGEMENT LLC

Astellas Venture Management LLC (AVM) is the corporate venture capital organization dedicated to reinforcing Astellas Pharma Inc. (Astellas) to accomplish the strategic goals. The venture capital activity of AVM is designated since 2005. Astellas, the ultimate parent company of AVM, headquartered in Tokyo is actively engaged in business as an R&D-driven global pharmaceutical company with the business philosophy to “Contribute toward improving the health of people around the world through the provision of innovative and reliable pharmaceutical products”. Through strategic investments in private early-stage companies, the funds aim to mutual-interact with Astellas, leading to partnering/collaboration in the future. AVM will be able to provide portfolio companies with invaluable R&D advice and assistance.

mogrify investor university of bristol

University of Bristol

The University of Bristol Enterprise Fund is an early-stage investment fund backing scientific and technological companies spun out of the University of Bristol or being supported by the University’s SETsquared incubator.

DR. DARRIN M. DISLEY OBE

Darrin is a renowned scientist, entrepreneur, angel investor and enterprise champion who has started, grown or invested in over 40 start-up life science, technology and social enterprises, raising $525 million USD in business financing and closing $650 million USD in commercial deals. He was CEO of Horizon Discovery Group plc for 11 years, during which he led the Company from start-up through a $113 million USD IPO, and rapid scale-up powered by multiple acquisitions of US peer companies to become a global market leader in gene editing and gene modulation technologies. He was awarded a lifetime Queen’s Award for Enterprise Promotion in 2016 for his work in promoting enterprise across the UK and appointed OBE in 2018 for his services to business and enterprise in the healthcare sector.

DR. JONATHAN MILNER

Jonathan, Founder of Abcam plc, is an experienced entrepreneur and investor and is passionate about supporting UK life science and high-tech start-ups. He has provided considerable investment and support to over 60 companies and has assisted three technology companies to IPO on the London AIM Stock exchange.

Jonathan gained his doctorate in Molecular Genetics at Leicester University after graduating in Applied Biology at Bath. From 1992–95, he was a post-doctoral researcher at Bath, following which he worked at the University of Cambridge in the lab of Professor Tony Kouzarides studying cancer. He identified the market opportunity for supplying high-quality antibodies to support protein interaction studies, and in 1998, founded Abcam with David Cleevely and Professor Tony Kouzarides.

Jonathan is Chairman of Axol Bioscience Ltd and Camallergy Ltd and non-executive director of PhoreMost Ltd, Syndicate Room Ltd and HealX Ltd.

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