The Potential of Pluripotent Stem Cells for ‘Off-the-Shelf’ Cell Therapy

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The Potential of Pluripotent Stem Cells for ‘Off-the-Shelf’ Cell Therapy

2021  |  Alessandra de Riva, Eirini Koutsouraki

Human pluripotent stem cells (PSC) are characterized by their undifferentiated status, infinite self-renewal capacity, and ability to differentiate into any cell type in the body. These characteristics make them an appealing source for therapeutic applications, from regenerative therapy to immuno-oncology. While PSC-based therapies have now reached the clinical trial stage, they are still in their infancy, and several hurdles need to be overcome for full translation into the clinic with uncompromised patient safety.

Featured in the October 2021 issue of European Biopharmaceutical Review (EBR), our team discusses the specific challenges associated with the development of PSC-based therapies, as well as allogeneic strategies to deliver safe and scalable therapeutic products and their progress-to-date.

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