Cell Therapy for Autoimmune Disease: Armored Tregs to the Rescue

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Cell Therapy for Autoimmune Disease: Armored Tregs to the Rescue

2021  |  Raul Elgueta, Cristina del Carmen Rosello

In disease states such as autoimmune disease, chronic viral infection, and transplant rejection, the immune system responds inappropriately to self-antigens or doesn’t resolve once the pathogen has been removed. Immunosuppressants may be used to reduce inflammation, but current biologic and small-molecule therapies must be administered over the long-term and can only alleviate symptoms. Regulatory T cells (Tregs) maintain a healthy immune response by suppressing inappropriate activation. And, in recent years, researchers have turned to Tregs to develop adoptive cellular therapies that can restore immune tolerance in autoimmune disease and transplantation – with minimal side effects.

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